Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 18;13(8):1463. doi: 10.3390/diagnostics13081463

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Decision tree of CDI diagnostic strategies. (A) Decision tree of one-step NAAT alone pathway; (B) Decision tree of two-step algorithm with GDH/toxin followed by NAAT. Patients with positive tests, or false negative tests would be treated. Following treatment, patients could be cured from CDI, unresponsive to treatment, or dead. Patients who failed response to the initial treatment received the next line treatment. Patients who were cured from CDI may develop another CDI, where recurrence of CDI was assumed to occur at least 4 weeks after the previous infection. Up to two recurrences were modelled in all patients, including patients who had treatment failure. CDI: Clostridioides difficile infection; GDH: Glutamate Dehydrogenase; IV MNZ + VCM: Intravenous Metronidazole and Vancomycin; NAAT: Nucleic Acid Amplification Test.