Table 2.

List of DUBs, substrates, and functions which are associated with ovarian cancer.

DUBs	Subtypes of Cancer	Substrates	Functions	Proteins Related to Function	Expression in Cancer	Level of Expression	References
USP5	Serous, endometrioid	HDAC2	Cell cycle arrest, chemoresistance, apoptosis	p21, p27	Up	mRNA, protein	[95]
USP14	Serous, endometrioid	BCL-XL	Apoptosis, cell cycle arrest	PCNA, Cyclin A, Cyclin D1	Up	Protein	[96]
	Serous, endometrioid	BCL-6	Chemoresistance apoptosis,	Not determined	Up	Protein	[97]
USP15	Serous, endometrioid	p53 (R175H)	Tumor cell death	Not determined	Up	mRNA	[98]
USP13	Serous	ACLY, OGDH	Glutaminolysis, mitochondrial dysfunction, lipid synthesis	Not determined	Up	Copy number	[99]
	Serous, clear cell	MCL-1	Apoptosis	Not determined	Up	Protein	[100]
	Serous, mucinous	RAP80	DNA damage response, chemoresistance	BRCA1, CCDC98	Up	mRNA, protein	[101]
USP10	Serous, endometrioid	G3BP1	Cell proliferation, migration, invasion	Not determined	Up	mRNA	[102]
USP32	Serous, endometrioid	FDFT1	Tumor sphere formation (invasion)	ZEB1, FN1, CDH1, CDH2, Snail 1	Up	Protein	[103]
COPS5	Serous, endometrioid	p27	Cell proliferation, apoptosis	Akt	Up	mRNA, protein	[104,105]
PSMD14	Serous, endometrioid	PKM2	Cell viability, migration, invasion	Not determined	Up	mRNA, protein	[106]
USP17	Serous, clear cell, endometrioid	MCL-1	Chemoresistance, apoptosis	MGMT	Up	Protein	[107]
USP36	Serous, endometrioid	PrimPol	Chemoresistance, DNA replication stress	Not determined	Up	Protein	[108]
OTUB1	Serous, endometrioid	FOXM1	Cell cycle arrest, invasion	Snail, CDC25B, Cyclin B	Up	Protein	[109]
UCHL3	Serous, endometrioid	TRAF2	Inflammatory response, tumorigenesis, migration	NF-κB1	Up	mRNA, protein	[110]
USP11	Serous	Snail	Cell proliferation, migration, invasion,	E-cadherin, N-cadherin, Fibronectin	Up	mRNA, protein	[111]
USP1	Serous, clear cell, endometrioid	Snail	Invasion, metastasis	ATM, ATR	Up	Protein	[112]
USP35	Serous	STING	Chemoresistance	TBK, IRF3, IFN-β	Up	Protein	[113]