Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 15;14(4):919. doi: 10.3390/genes14040919

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

A-to-I RNA editing events may alter miRNA competitions between their host genes and other genes. (A) Analysis procedures to uncover one possible mechanism of the trans-associations between RNA editing events and genes. (B) The enrichment results of the genes affected by editing-mediated miRNA competitions. (C) One RNA editing event in the 3′-UTR of APOL6 causes the binding loss of miRNAs and releases the miRNAs to regulate EEF1A1. (D) The frequency of this editing event is positively associated with the expression of APOL6 and negatively correlated to EEF1A1. APOL6 is highly expressed in severe PD samples. The editing event has higher frequencies in the samples with increased H&Y stages or tau protein levels. (E) The editing event may directly result in the overexpressions of APOL6 and indirectly cause the downregulations of 47 genes including EEF1A1 and 8 ribosome proteins. (F) The potential roles of this RNA editing event related to PD pathogenesis.