Table 6.

Diagnoses, co-occurring conditions, inheritance, and family phenotypes of individuals with GRIN2A variants in the early-onset psychosis cohort.

ID	Diagnosis	Co-Occurring Condition(s)	Inheritance	Carrier Parent Phenotype	Other Family History of Neuropsychiatric Disease
1	Early-onset schizophrenia	ASD	Paternal	Anxiety, depression, substance use disorder	None noted
2	Early-onset psychosis	OCD	Paternal	None noted	Maternal uncle: schizophrenia
3	Early-onset psychosis	Epilepsy, microcephaly	Maternal	ADHD	Brother: seizures Family history of bipolar disorder
4	Early-onset psychosis	Adenoidectomy, ADHD combined type, asthma, bipolar II disorder, obesity, type 2 diabetes mellitus	Unknown	Unknown	Mother: ADHD Father: PTSD and substance use Maternal grandmother: depression
5	Early-onset psychosis		Paternal	Severe OCD without psychotic symptoms	Maternal family history of bipolar disorder, schizophrenia, and ADHD
6	Early-onset psychosis	ADHD, ASD, Chiari malformation, seizures	Unknown	Unknown	Maternal grandmother: bipolar disorder
7	Early-onset psychosis	Depression, PTSD, reactive attachment disorder	Unknown	Unknown	Mother: seizures Father: childhood epilepsy (now outgrown)

Note: ASD = autism spectrum disorder; OCD = obsessive compulsive disorder; ADHD = attention-deficit/hyperactivity disorder; PTSD = post-traumatic stress disorder.