Table 2. Genetic features identified as important for the prediction of the number of MII oocytes after ovarian stimulation.
Genetic feature | Methoda | Gene | dbSNP IDb | Sequence variant | Allele frequencyc |
---|---|---|---|---|---|
IV-CA | CA | LHCGR | rs11887058 | NC_000002.12:g.48729336C>T | T = 0.428 |
PRLR | rs112461 | NC_000005.10:g.35063190A>T | T = 0.242 | ||
ESR1 | rs2207396 | NC_000006.12:g.152061247G>A | A = 0.356 | ||
IV8-6 | SOM | GDF9 | rs11739194 | NC_000005.10:g.132865538T>C | C = 0.515 |
rs17166294 | NC_000005.10:g.132866205T>C | C = 0.288 | |||
LHCGR | rs11887058 | NC_000002.12:g.48729336C>T | T = 0.428 | ||
FSHB | rs676349 | NC_000011.10:g.30234435A>G | G = 0.523 | ||
ESR1 | rs2273207 | NC_000006.12:g.152061190A>G | G = 0.117 | ||
ESR2 | rs928554 | NC_000014.9:g.64227477C>T | T = 0.731 | ||
IV22-2 | Haplotype | FSHR | rs80111020 | NC_000002.12:g.48962060 = | A = 0.909 |
rs6166 | NC_000002.12:g.48962782C>T | T = 0.701 | |||
IV41-8 | Haplotype | PRLR | rs387032 | NC_000005.10:g.35061629 = | T = 0.845 |
rs401694 | NC_000005.10:g.35062516 = | C = 0.765 | |||
rs112461 | NC_000005.10:g.35063190 = | A = 0.758 | |||
rs1057828 | NC_000005.10:g.35064413 = | C = 0.939 | |||
rs56251626 | NC_000005.10:g.35064922 = | C = 0.936 | |||
rs62355478 | NC_000005.10:g.35065548 = | C = 0.992 | |||
rs78373811 | NC_000005.10:g.35068146 = | G = 0.913 | |||
rs186609463 | NC_000005.10:g.35069864 = | G = 0.985 | |||
IV16-3 | Haplotype | GDF9 | rs75061517 | NC_000005.10:g.132866082 = | T = 0.689 |
rs17166294 | NC_000005.10:g.132866205 = | T = 0.712 | |||
rs30177 | NC_000005.10:g.132866719C>G | G = 0.924 |
a—features were determined using correspondence analysis (CA), self-organizing map (SOM) algorithm, and haplotype analysis followed by a reduction of the number of variants
b—dbSNP Reference SNP number according to the National Center for Biotechnology Information (NCBI) dbSNP database (https://www.ncbi.nlm.nih.gov/snp/, accessed: 2022-04-05)
c—allele frequencies were calculated for Group 2 consisting of 264 women.