Table 4.
Molecular biomarkers with diagnostic association in HNCUP.
| Biomarker | Sample Size | Diagnostic Association N° |
Over-Expressed N° (%) |
Down Regulated N° (%) |
Refs * |
|---|---|---|---|---|---|
| p16 | 167/391 | 5/9 | 5/9 (55.5) | 0/9 | [23,25,30,37,41] |
| HPV DNA/RNA | 200/495 | 4/7 | 4/7 (57.1) | 0/7 | [23,25,35,38] |
| EBV DNA/RNA | 79/79 | 4/4 | 3/4 (75) | 1/4 (25) | [25,33,34,45] |
| P53/p53 antibodies | 63/63 | 2/2 | 1/2 (50) | 1/2 (50) | [23,28] |
| Genetic panel assay | 1214/1214 | 2/2 | - | - | [26,29] |
| Ceramides | 8/8 | 4/4 | 3/4 (75) | 1/4 (25) | [27] |
| Salivary mRNA | 1/1 | 1/1 | 1/1 (100) | 0 | [31] |
| VEGF | 50/50 | 1/1 | 0 | 1/1 (100) | [36] |
| Other | 1/ 37 | 2/2 | 1/2 (50) | 1/2 (50) | [24,32] |
| TOTAL | 1783 | 25/32 | 18/32 | 5/32 |
N°: number of studies reporting the diagnostic association. Other: pRb and GATA3. Sample size: number of patients with diagnostic association/total number of patients on which the biomarker has been studied. Diagnostic association: N° of papers showing diagnostic association/N° of total analyzed papers dealing with the mentioned biomarker. * Concerning only the N° of papers dealing with diagnostic association of the mentioned biomarker.