Table 5.
Molecular biomarkers with prognostic association in HNCUP.
| Biomarker | Sample Size | Prognostic Association | Recurrence N° |
OS N° |
RT Response | Chemo Response |
Refs. * |
|---|---|---|---|---|---|---|---|
| p16 | 336/358 | Yes 6/8 | 4 ↑ | 4 ↑ | 0 | 0 | [23,25,40,42,43,44] |
| HPV DNA/RNA | 353/495 | Yes 4/7 | 3 ↑ | 4 ↑ | 0 | 0 | [23,39,40,44] |
| EBV DNA/RNA | 0/79 | No 0/4 | 0 | 0 | 0 | 0 | |
| P53/p53 antibodies | 63/63 | Yes 2/2 | 1 ↓ | 1 ↓ | 1 ↓ | 1 ↓ | [23,28] |
| Genetic panel assay | 1183/1214 | Yes (predictive) 1/2 | 1 ↑ | - | 0 | 1 ↑ | [26] |
| Ceramides | 2/8 | Yes 1/4 | 0 | 1 ↓ | 0 | 0 | [27] |
| Salivary mRNA | 0/1 | No 0/1 | 0 | 0 | 0 | 0 | |
| VEGF | 0/50 | No 0/1 | 0 | 0 | 0 | 0 | |
| Other | 1/37 | Yes 1/2 | 1 ↓ | 1 ↓ | 0 | 0 | [24] |
| TOTAL | 790 | 14/31 | 9 | 11 | 1 | 2 |
N°: number of studies reporting the association. Other: pRb and GATA3. ↑: high/positive expression if the biomarkers are associated with a better prognosis. ↓: high/positive expression if the biomarkers are associated with a worse prognosis. Sample size: number of patients with prognostic association/total number of patients on which the biomarker has been studied. Prognostic association: N° of papers showing prognostic association/N° of total analyzed papers dealing with the mentioned biomarker. * Concerning only the N° of papers dealing with prognostic association of the mentioned biomarker.