Figure 3.
Mechanism of crosslinking between chitosan and genipin molecules (A), SEM images and photographs of genipin crosslinked chitosan hydrogels prepared by different formulations (B) (the scale bars represent 200 μm). The inserted table shows formulation codes (F1–F7) by using different concentrations of chitosan (85–95% DDA and MW of 300-450 kDa) and genipin [reprinted with permission from ref. [119] Copyright © 2014, Elsevier]. At 2% w/v chitosan and 0.02% w/v genipin (C), the different DDA and MW of chitosan are used to fabricate hydrogels, samples a–e (inserted table). SEM images show surface (a-1 to e-1) and cross-sectional (a-2 to e-2) morphologies of genipin crosslinked chitosan hydrogels (the scale bars represent 100 μm) [reprinted with permission from ref. [120] Copyright © 2021, Elsevier].