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. 2023 Apr 14;24(8):7258. doi: 10.3390/ijms24087258

Figure 2.

Figure 2

CD4+ T cells differentiate and proliferate into Th1, Th2, and Th17 cells. Th17 and Th1 cells secrete proinflammatory cytokines, but Th2 secrete ant-inflammatory cytokines. Depletion of Tregs worsens mice’s cognitive impairment. Immunosuppressive anti-inflammatory cytokines are released by Tregs. While it is thought that immunoglobulin encourages and accelerates the uptake of Aβ plaques by microglia, it is also thought that the Aβ–IgG complex in the CSF has a negative impact on the cognitive health of AD patients. Created with BioRender (BioRender.com).