Figure 6.

Heatmap with the panphenome growth rates across multiple carbon sources. The top color bars indicate the total number of genes per genome (blue) and the total genes included in the GEMs (purple). The right bar indicates if the carbon source was tested in Biolog with B. subtilis 168 and the growth result in vivo. The data were hierarchically clustered with the “manhattan” distance method. The α and β symbols represent HMV subgroups. The universal class contains carbon sources with more than 90% of the strains with growth, the core class contains between 30% and 90%, and the strain-specific class contains less than 30%. The B. subtilis strain names are not shown, and the carbon sources are identified with the reduced BiGG namespace IDs to facilitate the visualization. Growth rates were normalized with the number of carbons of each carbon source metabolite.