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M2d polarization. The binding of IL-6 to the IL-6R/gp130 receptor complex leads to the recruitment of JAK1/2, which in turn phosphorylates STAT3, leading to STAT3 dimerization and translocation into the nucleus, where it activates gene transcription. LIF belongs to the IL-6 family and binding of LIF to its receptor results in IL-6 production. Thus, M2d macrophages can consume IL-6 in an autocrine manner.
