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. 2023 Apr 15;24(8):7323. doi: 10.3390/ijms24087323

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Weighted gene co-expression network analysis (WGCNA). (A) A specific health-associated microbiome guild of four taxa significantly influences the association between Mediterranean diet score and fecal calprotectin in a 3-step manner. (B) The metabolite cluster mediates the negative association between the Mediterranean diet score and fecal calprotectin. (C) A combination of features (three taxa and four metabolites) demonstrates an even stronger mediating effect between the Mediterranean diet score and fecal calprotectin. Green arrows represent a positive association and red arrows represent a negative association. Abbreviations: MDS, Mediterranean diet score; FCP, fecal calprotectin; ACME, average causal mediation effect; prop. mediated; proportion mediated. Created with BioRender.com (accessed on 5 January 2023).