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Compound 1 induced apoptosis of glioma cells LN229. (a) LN229 were treated with graded concentrations of compound 1 and stained with PI and Annexin V-FITC for flow cytometry analyses; (b) compound 1 increase the expression Bax/Bcl-2, cytochrome c and cleaved caspase 3; (c) compound 1 could regulated protein expression in EGFR/PI3K/Akt/mTOR signaling pathway. (n = 3, * p < 0.05, ** p < 0.01, *** p < 0.001, compared to the control group. ## p < 0.01, compared to group 2 μM).
