Table II.

Average Flow Adhesion biomarker values at baseline and during vaso‐occlusion crisis (VOC).

Biomarker	Steady State*	VOC*	Significance †	Fold difference(95% CI) ‡
FA‐WB‐VCAM	282 (260–305)	320 (268–382)	0·16	12% (−1 to 26%)
FA‐WBC‐VCAM	404 (382–429)	417 (362–408)	0·56	7% (−4 to 18%)
FA‐WB‐Psel	29 (26–31)	34 (28–41)	0·015	36% (8–64%)
FA‐WBC‐Psel	110 (99–122)	134 (108–167)	0·056	41% (4–78%)

^*Steady State and VOC data are presented as geometric mean with 95% confidence interval.

^† Significance of the difference in biomarker values between steady‐state and VOC conditions was calculated with a mixed model accounting for the repeated measurements (see Methods) accounting for both inter‐ and intrasubject variability through inclusion of both fixed and random effects.

^‡ Fold difference, given in percent, was calculated as the ratio between adhesion values (VOC minus steady state)/(steady state), accounting for the repeat measurements and thus taking into consideration intersubject variability.