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. 2023 Apr 18;24(8):7428. doi: 10.3390/ijms24087428

Figure 7.

Figure 7

(A) The hydrogen bond network in wild-type CHD7, with T917 hydrogen bonding to E919 and W908, and E919 hydrogen bonding to S834. (B) The disruption of the hydrogen bond network in mutant CHD7. The introduction of the hydrophobic methionine causes the hydrogen bonds with E919 and W908 to be lost and M917 to flip away from the polar network. The mutation is highlighted in pink; the hydrogen bonds are highlighted in yellow dashed lines; residues belonging to the chromo 1 domain are highlighted in green.