Table 2.
The long-term impact of EDA1 replacement on XLHED symptoms, investigated at the age of 60 ± 3 months.
| Subject |
Body Length (cm) 1 |
Body Weight (kg) 1 |
Primary Teeth (Number) |
Permanent Teeth (Number) |
Pilocarpine- Induced Sweating (µL/30 min) |
Episodes of Hyperthermia during the Summer? |
Dry Eye Issues? |
Nosebleeds (Number per Year) |
Repeated Airway Infections? |
Dry Mouth? | Hoarse Voice? | Dry Skin? |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N1 | 106.5 14th perc. |
18.7 42nd perc. |
2 | 4 | 0 | yes | yes | 5 | yes | yes | yes | yes |
| N2 | 109 26th perc. |
17.6 24th perc. |
8 | 5 | 0 | yes | yes | 50 | yes | yes | yes | yes |
| N3 | 110 40th perc. |
18.7 44th perc. |
1 | 2 | 0 | yes | yes | 4 | yes | yes | yes | yes |
| P3 (single dose) |
108 41st perc. |
18.8 56th perc. |
4 | 8 | 7 | no | no | 2 | no | no | no | yes |
| P1 (two doses) |
105 10th perc. |
16.2 11th perc. |
1 | 9 | 41 | no | no | 0 | no | no | no | no |
| P2 (two doses) |
106 14th perc. |
16.5 14th perc. |
1 | 7 | 50 | no | no | 0 | no | no | no | no |
1 Length and weight percentiles (perc.) indicated.