Table 2.
A summary of the cytokines produced by CD4 lymphocytes and their main subpopulations in basal conditions (medium) and after PMA stimulation. ↑ = Increased in our study; ↓ = decreased in our study; ___ = No variation.
| CD4 Lymphocytes | CD4 Naïve | CD4 Effector | CD4 Effector Memory | CD4 Central Memory | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Medium | PMA | Medium | PMA | Medium | PMA | Medium | PMA | Medium | PMA | |
| IFN-γ | __________ | __________ | __________ | __________ | __________ | __________ | __________ | __________ | __________ | ↓ in SCI-LCP and SCI-ECP versus HC |
| IL-10 | ↑ in SCI-LCP when compared to HC and SCI-SP | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP when compared to HC and SCI-SP (also ↑ relative to HC) | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP and SCI-SP when compared to HC |
| IL-17 | __________ | __________ | ↑ in SCI-LCP and SCI-ECP when compared to HC | __________ | __________ | __________ | __________ | __________ | __________ | __________ |
| IL-9 | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP and SCI-ECP when compared to HC | ↑ in SCI-LCP when compared to HC | __________ | __________ | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP and SCI-ECP when compared to HC | ↑ in SCI-LCP when compared to HC | __________ |
| TNF-α | ↑ in SCI-SP when compared to HC | ↑ in SCI-SP when compared to HC | __________ | ↑ in SCI-SP when compared to HC | __________ | __________ | __________ | __________ | __________ | ↑ in SCI-SP when compared to HC and with SCI-LCP |
| IL-2 | __________ | __________ | __________ | __________ | __________ | __________ | __________ | __________ | __________ | __________ |