Table 3.
A summary of the cytokines produced by CD8 lymphocytes and their main subpopulations in basal conditions (medium) and after PMA stimulation. ↑ = Increased in our study; ↓ = decreased in our study; ___ = No variation.
| CD8 Lymphocytes | CD8 Naïve | CD8 Effector | CD8 Effector Memory | CD8 Central Memory | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Medium | PMA | Medium | PMA | Medium | PMA | Medium | PMA | Medium | PMA | |
| IFN-γ | ↑ in SCI-LCP when compared to HC | __________ | ↑ in SCI-LCP when compared to HC | __________ | __________ | ↑ in SCI-ECP when compared to SCI-SP | __________ | ↓ in SCI-LCP when compared to SCI-ECP | __________ | __________ |
| IL-10 | ↑ in SCI-LCP when compared to HC and SCI-SP | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP when compared to HC and SCI-SP | ↑ in SCI-LCP and SCI-ECP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP, SCI-ECP, and SCI-SP when compared to HC |
| IL-17 | __________ | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP when compared to HC | __________ | __________ | __________ | __________ | __________ | ↑ in SCI-LCP and SCI-ECP when compared to HC |
| IL-9 | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP, SCI-ECP, and SCI-SP when compared to HC | ↑ in SCI-LCP and SCI-ECP when compared to HC | ↑ in SCI-LCP, SCI-ECP, and SCI-SP when compared to HC | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP, SCI-ECP, and SCI-SP when compared to HC | ↑ in SCI-LCP when compared to HC and SCI-ECP | ↑ in SCI-LCP and SCI-SP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-LCP and SCI-ECP when compared to HC |
| TNF-α | __________ | ↑ in SCI-SP when compared to HC | ↑ in SCI-LCP and SCI-ECP when compared to HC | ↑ in SCI-LCP when compared to HC | ↑ in SCI-ECP when compared to SCI-SP and SCI-LCP | __________ | __________ | __________ | ↑ SCI-ECP and SCI-SP when compared to HC and SCI-LCP (also ↑ relative to HC) | ↑ in SCI-SP when compared to HC and with SCI-LCP |
| IL-2 | __________ | __________ | __________ | __________ | ↑ in SCI-LCP when compared to HC | __________ | ↑ in SCI-LCP when compared to HC | __________ | ↑ in SCI-LCP when compared to HC | __________ |