Comparison of apoA-I structure and antioxidant ability in the presence of carboxymethyllysine (CML) and CIGB-258. (A) Measurement of the wavelength maximum fluorescence of the Trp emission scanning spectrum (Ex = 295 nm, Em = 305–400 nm) during 48 h incubation with apoA-I and CML under the absence or presence of CIGB-258. The data are expressed as mean ± SEM from three independent measurements with duplicate samples. ***, p < 0.001 versus apoA-I alone. (B) Measurement of ferric ion reduction ability (FRA) with apoA-I during 60 min incubation with CML and CIGB-258. **, p < 0.01 versus PBS + apoA-I + CML; ***, p < 0.001 versus PBS + apoA-I + CML; ns, not significant.