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. 2023 Apr 12;24(8):7152. doi: 10.3390/ijms24087152

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Zinc is involved in ryanodine receptor functions. Schematic of the zinc-mediated function of RyR2 in the SR. Aberrant intracellular zinc levels regulate calcium release via RyR2 and mitsugumin 23 from the SR.