Table 3.
Circulating levels of organ injury biomarkers in a porcine BI+HS model.
| Biomarkers | Baseline (BL) | 1 h Post-BI | 3 h Post-BI | 6 h Post-BI | 12 h Post-BI | 24 h Post-BI |
|---|---|---|---|---|---|---|
| Troponin I (pg/L) | 17.9 ± 13.59 | 40.28 ± 30.09 | 75.67 ± 38.25 | 374.48 ± 392.49 * | 2461 ± 2648.02 * | 1711.3 ± 2525.21 |
| Myoglobin (ng/mL) | 52.75 ± 9.03 | 90.00 ± 10.23 * | 62.50 ± 10.08 | 188.75 ± 204.98 * | 491.25 ± 333.75 * | 905.67 ± 964.93 |
| GFAP (ng/mL) | 0.20 ± 0.34 | 0.59 ± 0.56 | 0.86 ± 0.99 | 3.72 ± 5.34 | 0.86 ± 3.72 | 0.66 ± 0.74 |
| p-NF-H (ng/mL) | 14.54 ± 1.93 | 14.60 ± 1.56 | 15.26 ± 0.88 | 15.20 ± 0.16 | 15.56 ± 0.74 | 15.40 ± 0.90 |
| Total bilirubin (mg/dL) | 0.09 ± 0.04 | 0.14 ± 0.08 | 0.12 ± 0.03 | 0.10 ± 0.07 | 0.20 ± 0.08 | 0.60 ± 0.44 * |
| AST (U/L) | 27.20 ± 22.71 | 110.00 ± 164.91 | 35.50 ± 26.34 | 58.75 ± 6.90 * | 91.75 ± 21.69 * | 174.00 ± 206.41 |
| Creatinine (mg/dL) | 0.57 ± 0.29 | 0.72 ± 0.40 | 0.73 ± 0.06 | 0.79 ± 0.12 | 0.75 ± 0.15 | 0.58 ± 0.22 |
| PT (second) | 13.38 ± 0.35 | 14.28 ± 1.88 * | 14.20 ± 0.34 | 13.85 ± 0.31 | 13.85 ± 0.53 | 14.48 ± 0.95 * |
| aPTT (second) | 26.00 ± 7.22 | 25.06 ± 9.43 | 24.37 ± 4.74 | 24.58 ± 5.99 | 27.00 ± 4.38 | 35.89 ± 13.39 |
Notes: Data were presented as mean ± SD; statistical analysis was performed by the Mann–Whitney test. * p < 0.05 vs. BL. aPTT, activated partial thromboplastin time; AST, aspartate transaminase; GFAP, glial fibrillary acidic protein; p-NF-H, high molecular weight phosphorylated neurofilament; PT, prothrombin time.