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. 2023 Apr 19;24(8):7511. doi: 10.3390/ijms24087511

Figure 3.

Figure 3

Cycloxaprid acted on cockroach DUM neurons as a partial agonist. (A) Representative currents elicited by acetylcholine and cycloxaprid on cockroach DUM neurons. The concentrations (µM) were provided above the currents following drug name, acetylcholine (ACh), and cycloxaprid (Cyc). (B) Concentration-response curve for inward currents induced by cycloxaprid (n = 12). The currents were normalized to the maximum currents elicited by 1000 µM ACh, as indicated by the blank diamond (◊). A separate filled diamond (♦) showed the normalized currents from 1000 µM Cyc. (C) Representative currents elicited by the application of ACh and co-application of ACh and Cyc on cockroach neurons (n = 15). Concentrations were provided following drug names. + meant ACh plus Cyc. (D) Cyc concentration-dependent inhibition on inward currents elicited by 1000 µM ACh on cockroach neurons (n = 14–20). The currents were normalized to the maximum currents elicited by 1000 µM ACh. Data were presented as mean ± SEM. We performed one-way ANOVA with Tukey’s multiple comparisons. Different letters indicated significant differences at 0.05 level.