Table 1.
Agonist potency of acetylcholine, imidacloprid, and cycloxaprid on recombinant receptor Nlα1/β2 expressed in Xenopus oocytes.
| Agonist | Nlα1/β2 | Nlα1Y151S/β2 | ||||||
|---|---|---|---|---|---|---|---|---|
| Imax (nA) | EC50 (µM) | Hill Coefficient | n | Imax (nA) | EC50 (µM) | Hill Coefficient | n | |
| Acetylcholine | 262.19 ± 14.33 a | 27.36 ± 3.30 a | 1.14 | 7 | 258.72 ± 18.53 a | 30.08 ± 4.15 a | 1.06 | 6 |
| Imidacloprid | 186.26 ± 13.75 b | 71.01 ± 5.24 c | 1.17 | 6 | 53.76 ± 8.92 c | 162.25 ± 11.43 c | 1.13 | 6 |
| Cycloxaprid | 154.52 ± 15.02 b | 49.12 ± 4.07 b | 1.08 | 12 | 98.82 ± 11.04 b | 95.06 ± 7.18 b | 1.15 | 11 |
One-way ANOVA with Tukey’s multiple comparisons was used to compare the Imax and EC50 of different chemicals on the recombinant receptors. Data in the table were mean ± SEM. The lowercase letters in the same column indicated the significant difference at 0.05 level.