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. 2023 Apr 10;24(8):6999. doi: 10.3390/ijms24086999

Figure 1.

Figure 1

(A) Blood vessel projection image from bone to bone marrow (Reprinted with permission from Ref. [2], Copyright 2014, Springer Nature). (B) In the hematopoietic stem cell niche, cells compete for scarce nutrients and oxygen (Reprinted with permission from Ref. [1], Copyright 2010, Elsevier). (C) HIF signaling pathway (Reprinted with permission from Ref. [11], Copyright 2020, Elsevier). (D) Hypoxic microenvironment in bone marrow. * = Estimated conversion to pO2 from mm Hg(Reprinted with permission from Refs. [5,12], Copyright 2017, Elsevier).