Table 2. Etiological study of the patients.

	Genes/ variants	Classification	n
Complement dysregulation (genetic analysis performed in 6 patients)	C3: c.193A>C, p.(Lys65Gln) in homozygosity	Likely pathogenic variant	1
	CFI: c.530T>A, p.(Asn177Ile) in heterozygosity (plus 2 risk haplotypes in CFH and in MCP)	VUS	1
	CFH: c.3653G>T, p.(Cys1218Phe) in heterozygosity		1
	Complete homozygous deletion of CFHR1 and CFHR3 (with anti-factor H antibodies production)		1
	Complete homozygous deletion of CFHR1 and CFHR3 (without anti-factor H antibodies production)		1
Specific infectious agent (infectious etiological search performed in 16 patients)	E. coli		5
	S. pneumoniae		2

CFI: complement factor I; CFH: complement factor H; CFHR1: complement factor H-related protein 1; CFHR3: complement factor H-related protein 3; MCP: membrane cofactor protein; VUS: variant of unknown significance.