Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 27;14:2421. doi: 10.1038/s41467-023-38160-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — The schematic diagram illustrates the POLD1-MYC axis driving the proliferation and metastasis of BLCA. In BLCA, POLD1 is upregulated due to amplification, MYC transcriptional activation and other causes. POLD1 competitively binds MYC with FBXW7 to reduce the ubiquitination degradation of MYC. Thus, POLD1 upregulates MYC and promotes the proliferation and metastasis of BLCA. At the transcriptional level, POLD1 can bind with MYC in the form of a complex to the promoter of the MYC target gene to increase the transcriptional capacity of MYC. In addition, MYC can also bind to the promoter region of POLD1 and activate POLD1 transcription. Thus, a POLD1-MYC positive feedback loop is formed to promote the proliferation and metastasis of BLCA. Ub ubiquitin, UPS ubiquitin-proteasome system.