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. 2023 Apr 27;13:6874. doi: 10.1038/s41598-023-33932-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotype of DNMT1 knockdown cells (a) Growth curves of doxycycline induced DNMT1 knockdown cells and control cells (n = 4 per condition per time-point). (b) Unsupervised hierarchical clustering heatmap of the 40 most differentially expressed genes between doxycycline induced DNMT1 knockdown cells and control cells. (c) heatmap of the expression of the writers (DNMT genes) and erasers (TET enzymes) of DNA methylation in doxycycline induced DNMT1 knockdown cells and control cells. (d) Distribution of genes on chromosomes as determined by ShinyGO 0.76⁸¹. Chi-square test p = 5.8E-08. (e) Violin plots of the β-values for genes, promoters and CGIs for the differentially expressed genes (p adj < 0.05). Statistical test: paired Wilcoxon signed-rank test.(f) Morphology of control cells and cells with hypomethylated genomes. Arrowheads denote cells with abnormal nuclear morphology.