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. 2023 Apr 27;13:6874. doi: 10.1038/s41598-023-33932-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mutational impact of global DNA methylation loss (a) Box-plot with the individual data points of the number of single base substitutions per clone. Each clone is represented by a unique color. (b) Box-plot with the individual data points of the number of indels per clone. Each clone is represented by a unique color. Same color scheme as in a. (c) Average mutational spectra of (left) control clones and (right) hypomethylated DNMT1 knockdown clones. (d) Average mutational profiles of (top) hypomethylated DNMT1 knockdown clones and (bottom) control clones. (e) Cosine similarity between the mutational profiles of hypomethylated DNMT1 knockdown clones and control cells. (f) Circos plots from a clone with (left) normal DNA methylation levels and (right) a hypomethylated DNMT1 knockdown clone. Arrowhead denotes a chromothripsis event at the q-arm of chromosome 19, which was observed in 2 out of 3 clones.