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. 2023 Apr 27;13:6874. doi: 10.1038/s41598-023-33932-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of global DNA methylation loss on chromosomal instability (a) Single cell DNA sequencing results showing the copy number state per chromosome per cell for (top) control clones and (bottom) hypomethylated DNMT1 knockdown clones. Each row represents a single cell and each column represents a chromosome. For each condition 384 cells were sorted. Shown are the cells with good quality libraries. (b) Aneuploidy and heterogeneity scores for (left) control clones and (right) hypomethylated DNMT1 knockdown clones calculated with Aneufinder. Each dot represents a chromosome. (c) Reduced DNA methylation levels in pericentromeric regions of chromosomes 2, 3, 10, and 18 upon DNMT1 knockdown as determined by Nanopore DNA sequencing. Coordinate values are indicated.