Table 2.
The anti-PRV activity of compound 45 in BHK-21, PK-15, and Vero cells
| Compound | Cell line | CC50a (μM) | IC50b (μM) | SIc |
|---|---|---|---|---|
| 45 | BHK-21 | >30 | 0.039 ± 0.003 | >769 |
| PK-15 | >30 | 0.091 ± 0.09 | >329 | |
| Vero | >30 | 0.052 ± 0.021 | >576 |
a
BHK-21, PK-15, or Vero cells were treated with different concentrations of each compound at 37 °C for 48 h. The cell viability was determined by a CCK-8 kit, and CC50 values were calculated.
b
BHK-21, PK-15, or Vero cells were infected with PRV (MOI = 0.1) and then treated with different concentrations of each compound for 24 h. Supernatants were harvested to determine the virus production by a plaque assay. IC50 values were calculated (mean ± SD).
c
Selectivity index; SI = CC50/IC50.