Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 14;14:1132265. doi: 10.3389/fimmu.2023.1132265

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Xu, Zhang, Zhou, Lu, Xu, Wu, Zhang, Wu, Xu, Shi, Wei, Li and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Anti-inflammatory effects of C498. (A), DEGs among different treatment groups. Genes with fold change (FC) ≥ 2 and P-adjust ≤ 0.05 were considered as significantly differentially expressed genes. (B) Venn diagram of DEGs among indicated comparison groups. (C) Fold change values (FC) of canonical inflammatory factors enriched in 551 DEGs in (B). D-F, The normalized expression (TPM levels) of IL-6 (D), TNF (E) and CXCL10 (F) was graphed. *P < 0.05 is considered significant. (G), The top 25 KEGG enrichment analysis of the upregulated 511 DEGs in (B). (H), The top 25 of KEGG enrichment of downregulated DEGs between C498_LPS vs LPS groups. (I), The decreased upstream regulators IRF7-IFNB-TNFSF10 related networks of C498_LPS vs LPS in IPA analysis. (J), The decreased immune cell trafficking functions of C498_LPS vs LPS in IPA analysis.