Figure 3.

Amino acid sequence alignment of ScCD8α with CD8αs from different vertebrate species, with secondary structure elements indicated. Black arrows above the alignment indicate β-strands. Green numbers denote cysteines that form disulfide bonds, CDRs are outlined with red boxes. The residues conserved in the sampled species are shaded gray. The aa residues conserved in specific vertebrate lineages are marked with colored boxes. The hydrophobic core or predicted core are highlighted with colored rectangles. Amino acid identities between ScCD8α and the listed CD8α molecules are shown at the end of each sequence. The consensus sequence is shown at the bottom of the alignment. His28 in ScCD8α IgSF V domain is indicated by “▾”.