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. 2023 Jan 25;15(5):1255–1275. doi: 10.1016/j.jcmgh.2023.01.004

Figure 2.

Figure 2

Antibiotic pretreatment could reduce the abundance, diversity, and richness of the gut microbiota and change its composition. (A) Rank abundance curve of WT and ABX mice. (B) α diversity comparison: Shannon index, Simpson index, ACE index, and Chao index of WT and ABX mice. (C) β diversity of clustering analysis: PCA, PCoA, and NMDS analysis of WT and ABX mice at the operational taxonomic unit (OTU) level. (D and E) Comparison of composition of gut microbiota at the phylum level (D) and at the genus level (E) between WT and ABX mice. (F) Linear discriminant analysis (LDA) effect size (LEfSe) analysis with | LDA | ≥2. Fecal samples from WT (n = 5) and ABX (n = 5) mice were analyzed by 16S rRNA sequencing. Statistical comparisons were carried out by Student t test and ANOSIM analysis except LEfSe analysis using the nonparametric Kruskal–Wallis sum-rank test and Wilcoxon rank-sum test. P < .05 indicates significant differences.