TABLE 1.

Clinical trials with natural form of phytate in the last 5 years.

References	Design	Treatment	Patients	Results
Proietti et al. (2017)	Clinical trialRandomizedDouble-blind reference-controlled	Phytic acid(200 mg)/dayDuration: 6 months	AdultBreast Cancern = 20	-Phytate administration decreased the side effects of chemotherapy and increased the quality of life
Sanchis et al. (2018)	Clinical trialRandomizedCrossoverOpen study	Phytate(3 mg × 380 mg)/dayDuration: 3 months	AdultT2DMn = 35	-The level of AGEs and HbA1c was lower in the IP6 diet group compared to the non-IP6 dieted group-No adverse effect
Ikenaga et al. (2020)	Clinical trialRandomizedDouble-blind Crossover	Rice-derived phytic acid drink(50 mL)/visitDuration: -	AdultHealthyn = 48	-Urinary acid excretion and urinary acid synthesis decreased in the phytic acid drink-infused group compared to the control group-No adverse effect

AGEs, glycation end-products; HbA1c, glycated hemoglobin; T2DM, type 2 Diabetes Mellitus.