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Two cases of IDD treated with steroid hormones and NSAIDs: (A) Establishment of macrophage-NP crosstalk and drug suppression of inflammation (possibly converting acute inflammation to chronic inflammation). (B) Subligamentous herniation causes nerve injury, and macrophages accumulate around the nerve root instead of the NP; due to the NP immune barrier, macrophage-NP crosstalk is not established, and immune cells cannot phagocytize herniation, which is called immune deception.
