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. 2022 Mar 15;3(2):301–310. doi: 10.1016/j.bpsgos.2022.03.002

Figure 5.

Figure 5

Influence of real vs. sham theta burst stimulation (TBS) over time and by region of interest. Estimated marginal means across time (A) and regions of interest (B) are plotted with respect to treatment (real TBS: black lines, circles; sham TBS: gray lines, squares). The general linear model assessing change in functional connectivity included covariates for scalp-to-cortex distance, gender, Beck Depression Inventory-II, Alcohol Use Disorders Identification Test, and trait anxiety. (A) There was a significant time × treatment interaction on frontal pole connectivity during alcohol cues (F1,547 = 4.519, p = .01). (B) Across all regions of interest, functional connectivity to alcohol cues was consistently lower in the group receiving real TBS relative to sham. Error bars represent SEM. ACC, anterior cingulate cortex; B, bilateral; DS, dorsal striatum; Ins, insula; L, left; R, right; VS, ventral striatum.