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Inhibition of NLRP3 abrogates IL-1β and IL-18 cytokine production. BMDMs from C57BL/6 mice were stimulated with LCWE (10μg/ml) and with/without HgCl2 (20μM). In some cultures, the NLRP3 inhibitor MCC950 was added at 10nM 20-30 minutes prior to the addition of HgCl2. Secretion of IL-1β (A) and IL-18 (B) in supernatants was measured by ELISA (n=3, *p<0.0001).
