REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
mouse IgG	BioLegend	400124
mouse IgG	Thermo Fisher Scientific	02–6502
Alexa Fluor 594-mouse IgG	Thermo Fisher Scientific	A-11032
PE-mouse IgG	Thermo Fisher Scientific	P-852
FITC-rabbit IgG	abcam	ab97050
Alexa Fluor 488-rabbit IgG	Thermo Fisher Scientific	A-11008
CD3	Dako	A0452
FITC-CD3	BioLegend	344804
FITC-CD4	BioLegend	300506
FITC-CD4	BioLegend	357406
BV480-CD8	BD Biosciences	566121
FITC-CD14	BioLegend	325604
BV650-CCR7	BioLegend	353234
PE-Cy7-CD45	BioLegend	368532
BV570-CD45RA	BioLegend	304132
CD68	Thermo Fisher Scientific	PA5-32331
CD68	Cell Signaling Technology	76437
CD96	Thermo Fisher Scientific	PA5-97568
CD96	BioLegend	338402
PE-CD96	BioLegend	338406
BV421-CD96	BioLegend	338418
PE-PD-1	BioLegend	329906
PE/Dazzle594-TIGIT	BioLegend	372716
BV711-CD226	BioLegend	338334
PE/Cy5-TIM3	BioLegend	345052
PE/Cy7-LAG3	Thermo Fisher Scientific	25-2239-42
CD155	Thermo Fisher Scientific	MA5-13493
CD155	BioLegend	337502
CD155	Thermo Fisher Scientific	MA5-29762
PE-CD155	BioLegend	337507
CD63	Santa Cruz Biotechnology	sc-5275
GM130	abcam	ab52649
ERGIC-53/p58	Sigma	E1031
LAMP2A	abcam	ab18528
Calnexin	ABclonal	A15631
EEA1	ABclonal	A0592
LC3	MBL	PM036
HSP60	Santa Cruz Biotechnology	sc-13115
PerCP/Cy5.5-IFN-γ	BioLegend	502526
IL-9	BioLegend	507704
IL-9	proteintech	66144-1-Ig
BV421-IL-9	BD Biosciences	564254
Biological samples
PBMC	Stanford University School of Medicine/Mayo Clinic	N/A
Chemicals, peptides, and recombinant proteins
Dynabeads Human T-Activator CD3/CD28	Thermo Fisher Scientific	11132D
Lymphoprep	Cosmo Bio USA	AXS-1114547
M-CSF	BioLegend	574806
IFN-γ	Sino Biological	11725
LPS	MilliporeSigma	L2630
Accutase Cell Detachment Solution	Innovative Cell Technologies	AT-104
DAPI	Thermo Fisher Scientific	D1306
Critical commercial assays
EasySep™ Human Monocyte Enrichment Kit	Stemcell Technologies	19058
EasySep™ human naive CD4 T cell isolation kit	Stemcell Technologies	19555
EasySep™ human CD4 T cell isolation kit	Stemcell Technologies	17952
Experimental models: Organisms/strains
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice	The Jackson Laboratory	IMSR_JAX:005557
Oligonucleotides
CD96 siRNA	horizon	L-020045-02-0005
control siRNA	horizon	D-001810-01-05
CD96 siRNA	Santa Cruz Biotechnology	sc-45460
control siRNA	Santa Cruz Biotechnology	sc-37007
Software and algorithms
ZEN Software	Carl Zeiss	RRID:SCR_018163
FlowJo Flow Cytometry Analysis FlowJo	FlowJo	RRID:SCR_00852
ImageJ	ImageJ	RRID:SCR_003070
Prism Software	GraphPad	RRID:SCR_002798