Figure 4.

CD4 and CD8 T cells are required for the efficacy of the anti-PD-1 + anti-CTLA-4 + IL-2 triple immunotherapy regimen

(A) Scheme of the timeline of the experiments selectively depleting CD4, CD8 T cells, or both T cell subsets.

(B) Bioluminescence images of the groups of mice at the three indicated time points.

(C) Quantification and statistical comparison (Kruskal-Wallis test) of the images in (B). Each symbol represents an individual mouse. Medians and 95% CI are shown.

(D) Overall survival of the experimental groups of mice.