Fig. 2.

Plaque analysis in early-stage atherosclerotic mice one month after treatment with a single dose of miR-145 micelles. (A) Cross sections of aortic roots of miR-145 micelle-treated mice stained with H&E. Yellow outlines indicate plaque area. Scale bar 500 μm. Quantification of (B) aortic root lesion sizes and (C) aortic root plaque necrotic core area, and (D) en face lesions of the aorta. (E) miR-145 expression in the aortic root quantified by RT-qPCR. ** indicates p < 0.01, **** indicates p < 0.0001.