Fig. 4.

Plaque analysis in mid-stage atherosclerotic mice two months after treatment with a single dose of miR-145 micelles. (A) H&E stains of aortic root cross sections of miR-145 micelle-treated mice two months after treatment. Yellow dashes delineate plaque area. Quantification of (B) aortic root lesion sizes and (C) aortic root plaque necrotic core area, and (D) en face lesions in the entire aorta. (E) miR-145 expression in the aortic root is elevated with miR-145 micelle treatment when quantified by RT-qPCR. * indicates p < 0.05, **** indicates p < 0.0001.