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. 2023 Apr 14;13:1141108. doi: 10.3389/fonc.2023.1141108

Table 2.

Revised TMNB classification for MF and SS.

Skin (T)
T1 Limited patches/plaques (covering <10% of the total skin surface)
 T1a Patches only
 T1b Plaques/papules ± patches
T2 Generalized patches/plaques (covering ≥10% of the total skin surface)
 T2a Patches only
 T2b Plaques/papules ± patches
T3 Tumor(s) ≥ 1cm diameter
T4 Confluence of erythema covering ≥80% of the body surface area
Lymph node (N)
N0 No clinically abnormal peripheral lymph nodes
N1 Clinically abnormal peripheral lymph nodes; dermatopathic lymphadenopathy or histopathological involvement by isolated atypical lymphocytes, without alteration of the lymph node architecture
 N1a Clone negative or equivocal
 N1b Clone positive and identical to skin
N2 Clinically abnormal peripheral lymph nodes; histopathological involvement by aggregates of atypical lymphocytes, without alteration of the lymph node architecture
 N2a Clone negative or equivocal
 N2b Clone positive and identical to skin
N3 Clinically abnormal peripheral lymph nodes; frank histopathological involvement and partial/complete effacement of the lymph node architecture
 N3a Clone negative or equivocal
 N3b Clone positive and identical to skin
Nx Clinically abnormal peripheral lymph nodes; without histopathological confirmation
Viscera (M)
M0 Without visceral involvement
M1 With visceral involvement
 M1a Bone marrow involvement
 M1b Non-bone marrow visceral involvement
Blood (B)
B0 Absence of significant blood involvement (< 250/µL of CD4+CD26- or CD4+CD7- cells)
 B0a Clone negative or equivocal
 B0b Clone positive and identical to skin
B1 Low tumor burden in the blood, but do not fulfill B2 criteria
 B1a Clone negative or equivocal
 B1b Clone positive and identical to skin
B2 High tumor load in the blood (CD4/CD8 ≥ 10; CD4+CD7- ≥ 40%; CD4+CD26- ≥ 30%; ≥ 1000/µL of CD4+CD26- or CD4+CD7- cells or other aberrant population of lymphocytes identified by flow cytometry)
 B2a Clone negative or equivocal
 B2b Clone positive and identical to skin
Bx Unable to quantify blood involvement