Table 2.
Revised TMNB classification for MF and SS.
Skin (T) | |
---|---|
T1 | Limited patches/plaques (covering <10% of the total skin surface) |
T1a | Patches only |
T1b | Plaques/papules ± patches |
T2 | Generalized patches/plaques (covering ≥10% of the total skin surface) |
T2a | Patches only |
T2b | Plaques/papules ± patches |
T3 | Tumor(s) ≥ 1cm diameter |
T4 | Confluence of erythema covering ≥80% of the body surface area |
Lymph node (N) | |
N0 | No clinically abnormal peripheral lymph nodes |
N1 | Clinically abnormal peripheral lymph nodes; dermatopathic lymphadenopathy or histopathological involvement by isolated atypical lymphocytes, without alteration of the lymph node architecture |
N1a | Clone negative or equivocal |
N1b | Clone positive and identical to skin |
N2 | Clinically abnormal peripheral lymph nodes; histopathological involvement by aggregates of atypical lymphocytes, without alteration of the lymph node architecture |
N2a | Clone negative or equivocal |
N2b | Clone positive and identical to skin |
N3 | Clinically abnormal peripheral lymph nodes; frank histopathological involvement and partial/complete effacement of the lymph node architecture |
N3a | Clone negative or equivocal |
N3b | Clone positive and identical to skin |
Nx | Clinically abnormal peripheral lymph nodes; without histopathological confirmation |
Viscera (M) | |
M0 | Without visceral involvement |
M1 | With visceral involvement |
M1a | Bone marrow involvement |
M1b | Non-bone marrow visceral involvement |
Blood (B) | |
B0 | Absence of significant blood involvement (< 250/µL of CD4+CD26- or CD4+CD7- cells) |
B0a | Clone negative or equivocal |
B0b | Clone positive and identical to skin |
B1 | Low tumor burden in the blood, but do not fulfill B2 criteria |
B1a | Clone negative or equivocal |
B1b | Clone positive and identical to skin |
B2 | High tumor load in the blood (CD4/CD8 ≥ 10; CD4+CD7- ≥ 40%; CD4+CD26- ≥ 30%; ≥ 1000/µL of CD4+CD26- or CD4+CD7- cells or other aberrant population of lymphocytes identified by flow cytometry) |
B2a | Clone negative or equivocal |
B2b | Clone positive and identical to skin |
Bx | Unable to quantify blood involvement |