Table 6.
Effect of MSCs on pulmonary function in eight included studies.
| Sources | Pulmonary function and imaging |
|---|---|
| Adas et al.
21
Turkey |
Oxygenation status: • PaO2/FiO ratio was lower in the treatment group during the treatment with no significant differences between groups • Duration of ventilator use in the treatment group was significantly lower than the control group after day 7 following infusion |
| Dilogo et al.
22
Indonesia |
N/A |
| Lanzoni et al.
19
United States |
N/A |
| Liang et al.
23
China *Case report |
CT features: • On days 8 and 13 after first infusion, CT images showed reduction of GGO |
| Monsel et al.
20
France |
Oxygenation
status: • PaO2/FiO2-ratio changes between D0 and D7 did not show any significant differences between treatment and control group • PaO2/FiO ratio showed significant increase within the treatment group from days 0 to 7 (p = 0.03) for alive patients remaining after 7 days • PaO2/FiO2 ratio within the control group did not show significant differences (p = 0.70) from days 0 to 7 |
| Rebelatto et al.
24
Brazil |
CT features: • CT images showed higher lung clearance in the treatment group compared with the control group based on the degree of opacification with statistical significance between baseline and month 4 (p = 0.01), and day 14 and month 4 (p = 0.01) |
| Shu et al.
25
China |
Oxygenation status: • On day 7, 66.67% of patients in the treatment group and 10.34% in the control group did not require supplemental oxygen • Time taken for oxygenation index return to normal was significantly shorter in the treatment group (p < 0.001) when compared with the control group CT features: • Two weeks after treatment, CT scores (p = 00.017), the number of lobes involved (p < 0.001), GGO (p = 0.0407), and consolidation (p = 0.0306) were significantly improved in the treatment group compared with the control group |
| Zhu et al.
26
China *Case report |
Oxygenation status: • On day 2 after infusion, SpO2 returned to normal level at 95% and above CT features: • On day 7 after infusion, CT images showed reduction of GGO and pneumonia infiltration |
CT, computerized tomography; GGO, ground-glass opacity; MSC, mesenchymal stromal/stem cell.