Table 1.
Clinicopathologic Correlation of PFKFB4 in HBV-Associated HCC Patients
| Clinicopathologic parameters | HCC cases |
||
|---|---|---|---|
| PFKFB4 overexpression (at 3-fold cut-off) (n = 46) |
PFKFB4 normal or underexpression (n = 54) | P valuea | |
| Gender | .2584 | ||
| Male | 32 (69.6%) | 43 (79.6%) | |
| Female | 14 (30.4%) | 11 (20.4%) | |
| Average patient age, y (range) | 49.07 (24–71) | 55.69 (29–74) | .0047b |
| Background liver disease | .2146 | ||
| Normal | 3 (6.8%) | 2 (4.0%) | |
| Chronic hepatitis | 22 (50.0%) | 19 (38.0%) | |
| Cirrhosis | 19 (43.2%) | 29 (58.0%) | |
| Tumor size | .0288c | ||
| ≤5 cm | 9 (20.5%) | 21 (42.0%) | |
| >5 cm | 35 (79.5%) | 29 (58.0%) | |
| Tumor encapsulation | .2891 | ||
| Present | 31 (70.5%) | 31 (58.5%) | |
| Absent | 13 (29.5%) | 22 (41.5%) | |
| Venous invasion | .0025b | ||
| Absent | 13 (28.3%) | 32 (59.3%) | |
| Present | 33 (71.7%) | 22 (40.7%) | |
| Tumor microsatellite formation | .3120 | ||
| Absent | 18 (39.1%) | 27 (50.9%) | |
| Present | 28 (60.9%) | 26 (49.1%) | |
| Liver invasion | .0669 | ||
| Absent | 23 (50.0%) | 35 (68.6%) | |
| Present | 23 (50.0%) | 16 (31.4%) | |
| Cellular differentiation | .0945 | ||
| Edmondson grades I–II | 14 (31.8%) | 25 (50.0%) | |
| Edmondson grades III–IV | 30 (68.2%) | 25 (50.0%) | |
| TNM tumor staging | .0355c | ||
| I–II | 11 (20.4%) | 25 (46.3%) | |
| III–IV | 34 (63.0%) | 29 (53.7%) | |
a
Fisher exact test
c
P < .05.
b
P < .01.