Table 2.
Clinicopathologic Correlation of PFKFB4 Overexpression in HBV-Associated HCC Patients With Wild-Type or Mutant TP53
| Clinicopathologic parameters |
TP53 wild-type HCC cases |
TP53 mutated HCC cases |
||||
|---|---|---|---|---|---|---|
| PFKFB4 overexpression (n = 9) | PFKFB4 normal or underexpression (n = 37) | Pa | PFKFB4 overexpression (n = 20) | PFKFB4 normal or underexpression (n = 18) | Pa | |
| Gender | .211 | .485 | ||||
| Male | 5 (55.6%) | 29 (78.4%) | 13 (65.0%) | 14 (77.8%) | ||
| Female | 4 (44.4%) | 8 (21.6%) | 7 (35.0%) | 4 (22.2%) | ||
| Average patient age, y (range) | 46.0 (24–74) | 53.8 (24–66) | .108 | 48.2 (36–71) | 56.5 (29–68) | .019b |
| Background liver disease | 1.000 | .012b | ||||
| Normal | 0 (0.0%) | 3 (8.8%) | 0 (0.0%) | 0 (0.0%) | ||
| Hepatitis | 6 (66.7%) | 17 (50.0%) | 11 (57.9%) | 2 (12.5%) | ||
| Cirrhosis | 3 (33.3%) | 14 (41.2%) | 8 (42.1%) | 14 (87.5%) | ||
| Tumor size | .442 | .003c | ||||
| ≤5 cm | 4 (44.4%) | 10 (29.4%) | 2 (10.5%) | 10 (62.5%) | ||
| >5 cm | 5 (55.6%) | 24 (70.6%) | 17 (89.5%) | 6 (37.5%) | ||
| Tumor encapsulation | .703 | .020b | ||||
| Present | 2 (22.2%) | 11 (31.4%) | 4 (26.7%) | 11 (68.2%) | ||
| Absent | 7 (77.8%) | 24 (68.6%) | 15 (73.3%) | 7 (31.8%) | ||
| Venous invasion | .264 | .019b | ||||
| Absent | 3 (33.3%) | 22 (59.5%) | 4 (20.0%) | 11 (61.1%) | ||
| Present | 6 (66.7%) | 15 (40.5%) | 16 (80.0%) | 7 (38.9%) | ||
| Tumor microsatellite formation | 1.000 | .119 | ||||
| Absent | 4 (44.4%) | 15 (41.7%) | 8 (40.0%) | 12 (66.7%) | ||
| Present | 5 (55.6%) | 21 (58.3%) | 12 (60.0%) | 6 (33.3%) | ||
| Liver invasion | .124 | .745 | ||||
| Absent | 4 (44.4%) | 25 (73.5%) | 12 (60.0%) | 9 (50.0%) | ||
| Present | 5 (55.6%) | 9 (26.5%) | 8 (40.0%) | 9 (50.0%) | ||
| Cellular differentiation | 1.000 | .132 | ||||
| Edmondson grades I–II | 4 (44.4%) | 14 (41.2%) | 3 (15.8%) | 7 (43.8%) | ||
| Edmondson grades III–IV | 5 (55.6%) | 20 (58.8%) | 16 (84.2%) | 9 (56.3%) | ||
| TNM tumor staging | 1.000 | .042b | ||||
| I–II | 3 (33.3%) | 14 (38.9%) | 4 (20.0%) | 10 (55.6%) | ||
| III–IV | 6 (66.7%) | 22 (61.1%) | 16 (80.0%) | 8 (44.4%) | ||
a
Fisher exact test.
b
P < .05.
c
P < .01.