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(A) Nrf2 and (B) HO-1 signaling pathway in cardiac tissue. The expression levels of Nrf2 and HO-1 were elevated with CGA treatment. Data are presented as the means ± SD. **** p < 0.0001 vs. the control group, ### p < 0.001, #### p < 0.0001 vs. the DOX group (n = 7). CGA: Chlorogenic acid (100 mg/kg); DOX: Doxorubicin (15 mg/kg); Nrf2: Nuclear factor erythroid 2–related factor 2; HO-1: Heme Oxygenase 1.
