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Effect of celecoxib on the caspase-3 activity in melanoma cell lines. (a) A2058 cells and (b) SAN cells were incubated with vehicle alone (0.5% (v/v) DMSO) or 40 or 80 µM celecoxib. Caspase-3 enzymatic activity is expressed as a fold increase with respect to untreated control cells and reported as the mean ± SE from at least three different experiments. ** p < 0.01, *** p < 0.001 compared to control cells.
