Table 2(a).

Univariate Cox model for outcome of histological change (i.e. from LC to CC or mixed histology and from CC to LC or mixed histology). ^a

Term	HR	HR 95% lower	HR 95% upper	p Value
Former smoking versus never smoker	1.078	0.673	1.728	0.754
Current smoking versus never smoker	0.855	0.482	1.515	0.591
Age at diagnosis	1.008	0.992	1.025	0.334
Male versus female	1.024	0.622	1.685	0.926
NSAID use	1.058	0.616	1.817	0.837
Aspirin use	0.867	0.521	1.442	0.582
PPI use	1.042	0.631	1.721	0.871
Statin use	0.809	0.460	1.421	0.460
Histamine-2 antagonist use	0.343	0.048	2.474	0.289
Antipsychotic medication use	1.186	0.730	1.928	0.490
Budesonide treatment	1.205	0.749	1.940	0.442
Prednisone treatment	2.609	1.249	5.451	0.011
Imodium treatment	1.260	0.832	1.908	0.274
Mesalamine treatment	0.835	0.472	1.478	0.536
Bismuth treatment	1.680	1.109	2.545	0.014
Other treatment options	0.684	0.371	1.261	0.224
Presence of symptoms	2.990	0.731	12.231	0.127
CC versus LC	0.270	0.170	0.430	<0.001

^aIndex biopsies with mixed MC findings were not included in the analysis, and only assessments with a definitive diagnosis of CC or LC were considered as the index diagnosis. Mixed MC findings were only included if found after an index biopsy.

CC, collagenous colitis; HR, hazard ratio; LC, lymphocytic colitis; NSAID, nonsteroidal anti-inflammatory drugs; PPI, proton-pump inhibitor.