Table 3(a).

Univariate Cox model for outcome of resolution (from LC or CC to normal colonic histology). ^a

Term	HR	HR 95% lower	HR 95% upper	p Value
Former smoking versus never smoker	0.901	0.582	1.396	0.641
Current smoking versus never smoker	1.161	0.734	1.837	0.524
Age at diagnosis	0.999	0.986	1.013	0.924
Male versus female	0.809	0.509	1.287	0.371
NSAID use	0.951	0.600	1.510	0.833
Aspirin use	1.624	1.100	2.399	0.015
PPI use	2.286	1.557	3.356	<0.001
Statin use	1.062	0.678	1.664	0.794
Histamine-2 antagonist use	0.503	0.124	2.039	0.336
Antipsychotic medication use	1.314	0.869	1.988	0.196
Budesonide treatment	2.009	1.381	2.923	<0.001
Prednisone treatment	1.441	0.668	3.109	0.352
Imodium treatment	0.812	0.558	1.180	0.274
Mesalamine treatment	0.397	0.201	0.786	0.008
Bismuth treatment	0.822	0.552	1.226	0.337
Other treatment options	0.893	0.539	1.479	0.661
Presence of symptoms	0.737	0.341	1.591	0.437
CC versus LC	0.736	0.511	1.061	0.100

^aIndex biopsies with mixed MC findings were not included in the analysis, and only assessments with a definitive diagnosis of CC or LC were considered as the index diagnosis. Mixed MC findings were only included if found after an index biopsy.

CC, collagenous colitis; HR, hazard ratio; LC, lymphocytic colitis; NSAID, nonsteroidal anti-inflammatory drugs; PPI, proton-pump inhibitor.