Table 3(b).

Multivariable Cox model for outcome of resolution (from LC or CC to normal colonic histology). ^a

Term	HR	HR 95% lower	HR 95% upper	p Value
Former smoking versus never smoker	0.862	0.532	1.397	0.546
Current smoking versus never smoker	1.140	0.677	1.918	0.623
Age at diagnosis	0.999	0.980	1.017	0.879
Male versus female	0.873	0.520	1.466	0.607
NSAID use	1.091	0.676	1.759	0.722
Aspirin use	2.104	1.337	3.311	0.001
PPI use	2.012	1.340	3.023	0.001
Statin use	1.022	0.626	1.668	0.931
Histamine-2 antagonist use	0.470	0.111	1.995	0.306
Antipsychotic medication use	1.215	0.774	1.907	0.397
Budesonide treatment	1.856	1.157	2.977	0.010
Prednisone treatment	1.445	0.631	3.311	0.384
Imodium treatment	0.842	0.526	1.347	0.473
Mesalamine treatment	0.398	0.191	0.829	0.014
Bismuth treatment	1.025	0.657	1.599	0.913
Other treatment options	1.270	0.673	2.399	0.461
Presence of symptoms	0.717	0.289	1.777	0.473
CC versus LC	0.701	0.468	1.049	0.084

^aIndex biopsies with mixed MC findings were not included in the analysis, and only assessments with a definitive diagnosis of CC or LC were considered as the index diagnosis. Mixed MC findings were only included if found after an index biopsy.

CC, collagenous colitis; HR, hazard ratio; LC, lymphocytic colitis; NSAID, nonsteroidal anti-inflammatory drugs; PPI, proton-pump inhibitor.